Systematic engineering of artificial metalloenzymes for new-to-nature reactions
نویسندگان
چکیده
منابع مشابه
Artificial metalloenzymes for enantioselective catalysis.
Artificial metalloenzymes have emerged over the last decades as an attractive approach towards combining homogeneous catalysis and biocatalysis. A wide variety of catalytic transformations have been established by artificial metalloenzymes, thus establishing proof of concept. The field is now slowly transforming to take on new challenges. These include novel designs, novel catalytic reactions, ...
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Catalysis is the most efficient strategy for the preparation of enantiopure products. Homogeneous and enzymatic catalyses are in many respects complementary in terms of substrate and reaction scope, operating conditions, enantioselection mechanism, etc. In terms of performance optimization, directed evolution methodologies outperform combinatorial ligand libraries. With the aim of combining the...
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هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...
15 صفحه اولModeling aspects of mechanisms for reactions catalyzed by metalloenzymes
Different models to treat metal-catalyzed enzyme reactions are investigated. The test case chosen is the recently suggested full catalytic cycle of manganese catalase including eight different steps. This cycle contains O—O and O—H activations, as well as electron transfer steps and redox active reactions, and is therefore believed to be representative of many similar systems. Questions concern...
متن کاملCatalyst design in oxidation chemistry; from KMnO4 to artificial metalloenzymes.
Oxidation reactions are an important part of the synthetic organic chemist's toolkit and continued advancements have, in many cases, resulted in high yields and selectivities. This review aims to give an overview of the current state-of-the-art in oxygenation reactions using both chemical and enzymatic processes, the design principles applied to date and a possible future in the direction of hy...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2021
ISSN: 2375-2548
DOI: 10.1126/sciadv.abe4208